Brefeldin A

Chemical name: (+)-Brefeldin A // Synonyms: Ascotoxin, Cyanein, Decumbin, Nectrolide, Synergisidin

  • Product code:LS-1014
  • CAS No.:20350-15-6
  • Formula:C16H24O4
  • Molecular weight:280.36 g/mol

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Lactone antibiotic produced by Eupenicillium brefeldianum. Activator of the sphingomyelin cycle; inhibitor of protein translocation from endoplasmic reticulum (ER) to the Golgi apparatus; Inhibitor of intracellular protein transport and protein secretion.


Nebenführ, A. et al., Brefeldin A: deciphering an enigmatic inhibitor of secretion. Plant Physiol. 2002;130(3):1102-8.

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