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Chemical name: (+)-Brefeldin A // Synonyms: Ascotoxin, Cyanein, Decumbin, Nectrolide, Synergisidin
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Lactone antibiotic produced by Eupenicillium brefeldianum. Activator of the sphingomyelin cycle; inhibitor of protein translocation from endoplasmic reticulum (ER) to the Golgi apparatus; Inhibitor of intracellular protein transport and protein secretion.
Nebenführ, A. et al., Brefeldin A: deciphering an enigmatic inhibitor of secretion. Plant Physiol. 2002;130(3):1102-8.
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