DBCO-PEG(5)-NHS

Chemical name: Dibenzoazacyclooctyne-penta(ethylene glycol)-propanoic acid succinimidyl ester // Synonyms: ADIBO-PEG(5)-NHS ester

  • Product code:RL-2460
  • CAS No.:1378531-80-6
  • Formula:C36H43N3O11
  • Molecular weight:693,74 g/mol

Starting at $250.00

Grouped product items
Qty Packing unit Price SKU
10 mg
$250.00
RL-2460.0010
25 mg
$387.50
RL-2460.0025
100 mg
$725.00
RL-2460.0100
500 mg
$2,025.00
RL-2460.0500
Safety Data Sheets
description

Cyclooctyne linker for conjugation via Diels-Alder-reaction, i.e. copper-free Click reaction with azides and tetrazines. The carboxylic acid function can be used to form amid bonds with amines.

references

Simon et al.; Facile Double-Functionalization of Designed Ankyrin Repeat Proteins using Click and Thiol Chemistries. Bioconjugate Chem. 2012; 23(2): 279.

Zeng et al.; 64Cu Core-Labeled Nanoparticles with High Specific Activity via Metal-Free Click Chemistry. ACS Nano. 2012; 6(6): 5209.

Arumugam et al.; [18F]Azadibenzocyclooctyne ([18F]ADIBO): A biocompatible radioactive labeling synthon for peptides using catalyst free [3+2] cycloaddition. Bioorg. Med. Chem.

Lett. 2011; 21: 6987.

Campbell-Verduyn et al.; Strain-Promoted Copper-Free Click Chemistry for 18F Radiolabeling of Bombesin. Angew. Chem. Int. Ed. 2011; 50: 11117.

Debets et al.; Aza-dibenzocyclooctynes for fast and efficient enzyme PEGylation via copper-free (3+2) cycloaddition. Chem. Commun. 2010: 46: 97.

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