DBCO-PEG(3)-BisSulfonThiol-Linker

Chemical name: Dibenzoazacyclooctyne-PEG(3)-BisSulfon-Thiol-Linker // Synonyms: 24-(azadibenzocyclooctyn-1-yl)-19,24-dioxo-4-(4-(3-tosyl-2-(tosylmethyl)propanoyl)benzoyl)-8,11,14-trioxa-4,18-diazatetracosane-1-sulfonic acid

  • Product code:RL-2480
  • Formula:C59H69N3O14S3
  • Molecular weight:1140.39 g/mol

Starting at $325.00

Grouped product items
Qty Packing unit Price SKU
10 mg
$325.00
RL-2480.0010
25 mg
$481.00
RL-2480.0025
100 mg
$1,677.00
RL-2480.0100
description

Cyclooctyne linker for conjugation via Diels-Alder-reaction, i.e. copper-free Click reaction with azides and tetrazines. The unique bis-sulfon linker integrates into existing disulfide bonds, eg. from enzymes or antibodies, maintaining the structural properties of the biomolecule.

references

Simon et al.; Facile Double-Functionalization of Designed Ankyrin Repeat Proteins using Click and Thiol Chemistries. Bioconjugate Chem. 2012; 23(2): 279.

Zeng et al.; 64Cu Core-Labeled Nanoparticles with High Specific Activity via Metal-Free Click Chemistry. ACS Nano. 2012; 6(6): 5209.

Arumugam et al.; [18F]Azadibenzocyclooctyne ([18F]ADIBO): A biocompatible radioactive labeling synthon for peptides using catalyst free [3+2] cycloaddition. Bioorg. Med. Chem. Lett. 2011; 21: 6987.

Campbell-Verduyn et al.; Strain-Promoted Copper-Free Click Chemistry for 18F Radiolabeling of Bombesin. Angew. Chem. Int. Ed. 2011; 50: 11117.

Debets et al.; Aza-dibenzocyclooctynes for fast and efficient enzyme PEGylation via copper-free (3+2) cycloaddition. Chem. Commun. 2010: 46: 97.

Site-Directed Chemical Modification and Cross-Linking of a Monoclonal Antibody Using Equilibrium Transfer Alkylating Cross-Link Reagents; Frederick A. Liberatore, Robert D. Comeau, James M. McKearin, Daniel A. Pearson, Benjamin Q. Belonfa III, Stephen J. Brocchini, John Kath, Terri Phillips, Kira Oswell, and Richard G. Lawton A; Bioconjugate Chem. 1990; 7: 36-50.

Sulfhydryl Site-Specific Cross-Linking and Labeling of Monoclonal Antibodies by a Fluorescent Equilibrium Transfer Alkylation Cross-Link Reagent; Renato B. del Rosario, Richard L. Wahl, Stephen J. Brocchini, Richard G. Lawton, and Richard H. Smith; Bioconjugate Chem. 1990; 1: 51-59.

Streptavidin-biotinylated IgG Conjugates: a Simple Procedure for Reducing Polymer Formation; Renato B. Del Rosario, Lee Ann Baron; Richard G. Lawton and Richard L. Wahl; Nucl. Med. Biol. 1992; 19(3): 417-421.

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