Chemical name: Dibenzoazacyclooctyne-PEG(3)-BisSulfon-Thiol-Linker // Synonyms: 24-(azadibenzocyclooctyn-1-yl)-19,24-dioxo-4-(4-(3-tosyl-2-(tosylmethyl)propanoyl)benzoyl)-8,11,14-trioxa-4,18-diazatetracosane-1-sulfonic acid

  • Product code:RL-2480
  • Formula:C59H69N3O14S3
  • Molecular weight:1140.39 g/mol

Starting at $325.00

Grouped product items
Qty Packing unit Price SKU
10 mg
25 mg
100 mg

Cyclooctyne linker for conjugation via Diels-Alder-reaction, i.e. copper-free Click reaction with azides and tetrazines. The unique bis-sulfon linker integrates into existing disulfide bonds, eg. from enzymes or antibodies, maintaining the structural properties of the biomolecule.


Simon et al.; Facile Double-Functionalization of Designed Ankyrin Repeat Proteins using Click and Thiol Chemistries. Bioconjugate Chem. 2012; 23(2): 279.

Zeng et al.; 64Cu Core-Labeled Nanoparticles with High Specific Activity via Metal-Free Click Chemistry. ACS Nano. 2012; 6(6): 5209.

Arumugam et al.; [18F]Azadibenzocyclooctyne ([18F]ADIBO): A biocompatible radioactive labeling synthon for peptides using catalyst free [3+2] cycloaddition. Bioorg. Med. Chem. Lett. 2011; 21: 6987.

Campbell-Verduyn et al.; Strain-Promoted Copper-Free Click Chemistry for 18F Radiolabeling of Bombesin. Angew. Chem. Int. Ed. 2011; 50: 11117.

Debets et al.; Aza-dibenzocyclooctynes for fast and efficient enzyme PEGylation via copper-free (3+2) cycloaddition. Chem. Commun. 2010: 46: 97.

Site-Directed Chemical Modification and Cross-Linking of a Monoclonal Antibody Using Equilibrium Transfer Alkylating Cross-Link Reagents; Frederick A. Liberatore, Robert D. Comeau, James M. McKearin, Daniel A. Pearson, Benjamin Q. Belonfa III, Stephen J. Brocchini, John Kath, Terri Phillips, Kira Oswell, and Richard G. Lawton A; Bioconjugate Chem. 1990; 7: 36-50.

Sulfhydryl Site-Specific Cross-Linking and Labeling of Monoclonal Antibodies by a Fluorescent Equilibrium Transfer Alkylation Cross-Link Reagent; Renato B. del Rosario, Richard L. Wahl, Stephen J. Brocchini, Richard G. Lawton, and Richard H. Smith; Bioconjugate Chem. 1990; 1: 51-59.

Streptavidin-biotinylated IgG Conjugates: a Simple Procedure for Reducing Polymer Formation; Renato B. Del Rosario, Lee Ann Baron; Richard G. Lawton and Richard L. Wahl; Nucl. Med. Biol. 1992; 19(3): 417-421.

Bulk or large quantity order?

Do you need larger quantities for your development or production?

Do you need further information about this product?

get in contact

Quick contact

Please send me more information about

We found other products you might like!