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Chemical name: 2-(1-hydroxy-5-((3aS,4S,6aR)-2-oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl)pentylidene)-5,5-dimethylcyclohexane-1,3-dione
|Molecular weight:||366,48 g/mol|
This cleavable linker is highly valuable for usage in protein enrichment and other applications. A linker based on the Dde protecting group leads to efficient release of targets under mild aqueous buffered conditions with 2% hydrazine.
Cleavable trifunctional biotin reagents for protein labelling, capture and release; Y. Yang and S. H. Verhelst; Chem Commun (Camb) 2013; 49: 5366-8. https://doi.org/10.1039/c3cc42076k
Versatile Dde-based primary amine linkers for solid phase synthesis; S. R. Chhabra, A. N. Khan, B. W. Bycroft; Tetrahedron Lett. 1998; 39: 3585-3588. https://doi.org/10.1016/S0004-4039(98)00555-3
Mapping the Binding Site of BMS-708163 on gamma-Secretase with Cleavable Photoprobes; N. Gertsik, C. W. Am Ende, K. F. Geoghegan, C. Nguyen, P. Mukherjee, S. Mente, U. Seneviratne, D. S. Johnson and Y. M. Li; Cell Chem Biol 2017; 24: 3-8. https://doi.org/10.1016/j.chembiol.2016.12.006
Transient affinity tags based on the Dde protection/deprotection strategy: Synthesis and application of 2-biotinyl-and 2-hexanoyldimedone; B. Kellam, W. C. Chan, S. R. Chhabra, B. W. Bycroft; Tetrahedron Lett. 1997; 38(30): 5391-5394. https://doi.org/10.1016/S0040-4039(97)01180-5
Comprehensive mapping of O-GlcNAc modification sites using a chemically cleavable tag; M. E. Griffin, E. H. Jensen, D. E. Mason, C. L. Jenkins, S. E. Stone, E. C. Peters and L. C. Hsieh-Wilson; Mol. BioSyst. 2016; 12: 1756-1759. https://doi.org/10.1039/C6MB00138F
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