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Chemical name: 2-(5-azido-1-hydroxypentylidene)-5,5-dimethylcyclohexane-1,3-dione // Synonyms: 5-azido-1-Dde-pentan-1-ol
|Molecular weight:||265,31 g/mol|
This cleavable linker is highly valuable for usage in protein enrichment and other applications. A linker based on the Dde protecting group leads to efficient release of targets under mild aqueous buffered conditions with 2% hydrazine.
Combining triazole ligation and enzymatic glycosylation on solid phase simplifies the synthesis of very long glycoprotein analogues; M. Galibert, V. Piller, F. Piller, V. Aucagne and A. F. Delmas; Chem. Sci. 2015; 6: 3617-3623. https://doi.org/10.1039/C5SC00773A
Mapping the Binding Site of BMS-708163 on gamma-Secretase with Cleavable Photoprobes; N. Gertsik, C. W. Am Ende, K. F. Geoghegan, C. Nguyen, P. Mukherjee, S. Mente, U. Seneviratne, D. S. Johnson and Y. M. Li; Cell Chem Biol 2017; 24: 3-8. https://doi.org/10.1016/j.chembiol.2016.12.006
Comprehensive mapping of O-GlcNAc modification sites using a chemically cleavable tag; M. E. Griffin, E. H. Jensen, D. E. Mason, C. L. Jenkins, S. E. Stone, E. C. Peters and L. C. Hsieh-Wilson; Mol. BioSyst. 2016; 12: 1756-1759. https://doi.org/10.1039/C6MB00138F
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