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Chemical name: N-alpha-(9-Fluorenylmethyloxycarbonyl)-O-t-butyl-L-tyrosine-3-(4-oxymethylphenoxy)propionic acid // Synonyms: (S)-3-(4-(((2-((((9H-fluoren-9-yl)methoxy)carbonyl)amino)-3-(4-(tert-butoxy)phenyl)propanoyl)oxy)methyl)phenoxy)propanoic acid, O-(1,1-Dimethylethyl)-N-[(9H-fluoren-9-ylmethoxy)carbonyl]-L-tyrosine [4-(2-carboxyethoxy)phenyl]methyl ester
|Molecular weight:||637,73 g/mol|
This Fmoc-amino acid-MPPA linker serves as precursor for the linkage to e.g. aminomethyl supports by standard coupling procedures. By this method, a low (max 0.5%) and reproducible epimerization level of the C-terminal amino acid in your peptide is guaranteed.
Improved approach for anchoring Nalpha-9-fluorenylmethyloxycarbonylamino acids as p-alkoxybenzyl esters in solid-phase peptide synthesis; F. Albericio, G. Barany; Int. J. Peptide. Protein. Res. 1985; 26(1): 92-97. https://doi.org/10.1111/j.1399-3011.1985.tb03182.x.
Amino acid derivatives used as agents bonding to a solid support; NeoMPS S.A. 2005; French Patent Application FR 0402973, International Patent Application WO2005/095332.
Molecular Signature for Receptor Engagement in the Metabolic Peptide Hormone Amylin; R. L. Bower, L. Yule, T. A. Rees, G. Deganutti, E. R. Hendrikse, P. W. R. Harris, R. Kowalczyk, Z. Ridgway, A. G. Wong, K. Swierkula, D. P. Raleigh, A. A. Pioszak, M. A. Brimble, C. A. Reynolds, C. S. Walker, D. L. Hay; ACS Pharmacol Transl. Sci. 2018; 1(1): 32-49. https://doi.org/10.1021/acsptsci.8b00002.
Structure activity relationship study on the peptide hormone preptin, a novel bone-anabolic agent for the treatment of osteoporosis; Z. Amso, R. Kowalczyk, M. Watson, Y.-E. Park, K. E. Callon, D. S. Musson, J. Cornish, M. A. Brimble; Org. Biomol. Chem. 2016; 14: 9225-9238. https://doi.org/10.1039/C6OB01455K.
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