Fmoc-NH-SS-OpNC

Chemical name: 2-((2-((9-Fluorenylmethyloxycarbonyl)amino)ethyl)disulfaneyl)ethan-1-yl p-nitrophenylcarbonate // Synonyms: Fmoc-NH-SS-OPNP, (9H-fluoren-9-yl)methyl (2-((2-(((4-nitrophenoxy)carbonyl)oxy)ethyl)disulfaneyl)ethyl)carbamate

  • Product code:RL-3540
  • Formula:C26H24N2O7S2
  • Molecular weight:540,61 g/mol

Starting at $210.00

Grouped product items
Qty Packing unit Price SKU
100 mg
$210.00
RL-3540.0100
250 mg
$420.00
RL-3540.0250
1 g
$1,200.00
RL-3540.1000
Safety Data Sheets
description

Fmoc-protected self-immolative linker for traceless bioconjugation. The p-nitrophenylcarbonate activating group reacts preferably with amine and other nucleophlies.


references

Disulfide-Based Self-Immolative Linkers and Functional Bioconjugates for Biological Applications; Z. Deng, J. Hu and S. Liu; Macromol Rapid Commun 2020; 41: e1900531. https://doi.org/10.1002/marc.201900531

Reduction-Triggered Transformation of Disulfide-Containing Micelles at Chemically Tunable Rates; Z. Deng, S. Yuan, R. X. Xu, H. Liang and S. Liu; Angew Chem Int Ed Engl 2018; 57: 8896-8900. https://doi.org/10.1002/anie.201802909

Growth inhibition of human ovarian carcinoma by a novel AvidinOX-anchored biotinylated camptothecin derivative; O. Minenkova, L. Vesci, R. De Santis, D. Santapaola, R. Cincinelli, L. Musso, S. Dallavalle and G. Giannini; Bioorg Med Chem Lett 2018; 28: 3312-3314. https://doi.org/10.1016/j.bmcl.2018.09.017

Photo- and Reduction-Responsive Polymersomes for Programmed Release of Small and Macromolecular Payloads; Z. Sun, G. Liu, J. Hu and S. Liu; Biomacromolecules 2018; 19: 2071-2081. https://doi.org/10.1021/acs.biomac.8b00253

A biotin-conjugated pyridine-based isatoic anhydride, a selective room temperature RNA-acylating agent for the nucleic acid separation; S. Ursuegui, R. Yougnia, S. Moutin, A. Burr, C. Fossey, T. Cailly, A. Laayoun, A. Laurent and F. Fabis; Org Biomol Chem 2015; 13: 3625-32. https://doi.org/10.1039/c4ob02636e

Water-soluble prodrugs of paclitaxel containing self-immolative disulfide linkers; M. Gund, A. Khanna, N. Dubash, A. Damre, K. S. Singh and A. Satyam; Bioorg Med Chem Lett 2015; 25: 122-7. https://doi.org/10.1016/j.bmcl.2014.10.088

Camptothecin delivery into hepatoma cell line by galactose-appended fluorescent drug delivery system; S. Dongbang, H. M. Jeon, M. H. Lee, W. S. Shin, J. K. Kwon, C. Kang and J. S. Kim; RSC Advances 2014; 4: 18744-18748. https://doi.org/10.1039/c4ra02588a

Mitochondrial thioredoxin-responding off-on fluorescent probe; M. H. Lee, J. H. Han, J. H. Lee, H. G. Choi, C. Kang and J. S. Kim; J Am Chem Soc 2012; 134: 17314-9. https://doi.org/10.1021/ja308446y

A two-photon fluorescent probe for thiols in live cells and tissues; J. H. Lee, C. S. Lim, Y. S. Tian, J. H. Han and B. R. Cho; J Am Chem Soc 2010; 132: 1216-7. https://doi.org/10.1021/ja9090676

Fluorescence imaging of cellular glutathione using a latent rhodamine; M. M. Pires and J. Chmielewski; Org Lett 2008; 10: 837-40. https://doi.org/10.1021/ol702769n

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