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Biotin-PABA
Chemical name: 4-(5-((3aS,4S,6aR)-2-oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl)pentanamido)benzoic acid // Synonyms: N-(+)-Biotinyl-4-aminobenzoic acid
- Product code:LS-4200
- CAS No.:6929-40-4
- Formula:C17H21N3O4S
- Molecular weight:363.43 g/mol
Starting at $500.00
description
Biotin-PABA is used as substrate for biotinidase, which cleaves biotin amide to release biotin in vivo. As byproduct, para amino benzoic acid is released, which can be quantified by either fluorescent or colorimetric methods. Biotin is an essential coenzyme for certain carboxylases and is used to modify histones and regulate gene transcription. Biotinidase has key roles in intestinal absorption of biotin, the transport of biotin in plasma, and in the regulation of histone biotinylation.
references
Quantitative Analytical Method for the Determination of Biotinidase Activity in Dried Blood Spot Samples; E. Szabó, I. Szatmári, L. Szõnyi, Z. Takáts; Anal. Chem. 2015; 87(20): 10573-10578. https://doi.org/10.1021/acs.analchem.5b02996.
Triazole biotin: a tight-binding biotinidase-resistant conjugate; A. I. Germeroth, J. R. Hanna, R. Karim, F. Kundel, J. Lowther, P. G. N. Neate, E. A. Blackburn, M. A. Wear, D. J. Campopiano, A. N. Hulme; Org. Biomol. Chem. 2013; 11: 7700-7704. https://doi.org/10.1039/C3OB41837E.
Design and Synthesis of ATP-Based Nucleotide Analogues and Profiling of Nucleotide-Binding Proteins; J. C. Wolters, G. Roelfes, B. Poolman; Bioconjugate Chem. 2011; 22(7): 1345-1353. https://doi.org/10.1021/bc100592q.
Biotinyl-methyl 4-(amidomethyl) benzoate is a competitive inhibitor of human biotinidase; K. A. Kobza, K. Chai, G. Sarath, J. M. Takacs, J. Zempleni; J. Nutr. Biochem. 2008; 19(2): 826-832. https://doi.org/10.1016/j.jnutbio.2007.11.002.
Qualitative colorimetric ultramicroassay for the detection of biotinidase deficiency in newborns; E. C. González, N. Marrero, A. Frómeta, D. Herrera, E. Castells, P. L. Pérez; Clin. Chim. Acta 2006; 369(1): 35-39. https://doi.org/10.1016/j.cca.2006.01.009.
Artificial Metalloenzymes: (Strept)avidin as Host for Enantioselective Hydrogenation by Achiral Biotinylated Rhodium-Diphosphine Complexes; M. Skander, N. Humbert, J. collot, J. Gradinaru, G. Klein, A. Loosli, J. Sauser, A. Zocchi, F. Gilardoni, T. R. Ward; J. Am. Chem. Soc. 2004; 126(44): 14411-14418. https://doi.org/10.1021/ja0476718.
Purification and characterization of human serum biotinidase; J. Chauhan, K. Dakshinamurti; J. Biol. Chem. 1986; 261(9): 4268-4275. https://doi.org/10.1016/S0021-9258(17)35656-9.
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