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Biotin-SS-Py

Chemical name: 5-((3aS,4S,6aR)-2-oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl)-N-(2-(pyridin-2-yldisulfaneyl)ethyl)pentanamide

Product code:LS-4230
CAS No.:112247-65-1
Formula:C17H24N4O2S3
Molecular weight:412,59 g/mol
Grouped product items
Qty Packing unit Price SKU
250 mg
$810.00
LS-4230.0250
New
description

This biotin derivative bears a terminal pyridyldithiol moiety. It can be used to prepare various biotinylated conjugates. Biotin can be subsequently detected e.g. via streptavidin or avidin. Pyridyl disulfides can be reacted with sulfhydryl groups to form disulfide bonds via a disulfide exchange reaction. As a result, pyridine-2-thione is released, which can be followed spectrophotometrically (lmax = 343 nm) to monitor the progress of the reaction.


references

Conjugation of Small Molecules to RNA Using a Reducible Disulfide Linker Attached at the 2’-OH Position through a Carbamate Function; F. Gauthier, A. Malher, J.-J. Vasseur, C. Dupouy, F. Debart; Eur. J. Org. Chem. 2019; 33: 5636-5645. https://doi.org/10.1002/ejoc.201900740.


Synthesis of Zwitterionic Diblock Copolymers with Cleavable Biotin Groups at the Function Points and Fabrication of Bioconjugates by Biotin-Streptavidin Coupling; J.-T. Wang, L. Wang, X. Ji, L. Liu, H. Zhao; Macromolecules 2017; 50(6): 2284-2295. https://doi.org/10.1021/acs.macromol.6b02665.


Transbilayer movement of phosphatidylserine in erythrocytes: inhibition of transport and preferential labeling of a 31 000-dalton protein by sulfhydryl reactive reagents; J. Connor, A. J. Schroit; Biochemistry 1988; 27(3): 848-851. https://doi.org/10.1021/bi00403a002.

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